Evolution of immune response against Neisseria meningitidis B:14:P1.7,16 before and after the outer membrane vesicle vaccine MenBvac

► We explore the immunity against B:14:P1.7,16 before and after the MenBvac campaign. ► Children (1-5 years) from a district in Normandy were sampled ► Seroprotection was defined by human Serum Bactericidal Activity titer ≥4. ► The long term effect of the 2 + 1 schedule might be lower than expected. ► A 3 + 1 MenBvac schedule is preferable.