Evaluation of synthetic infection-enhancing lipopeptides as adjuvants for a live-attenuated canine distemper virus vaccine administered intra-nasally to ferrets

► Cationic lipopeptides can enhance paramyxovirus infections in vitro and in vivo. ► Lipopeptide-mediated enhancement of paramyxovirus infection is independent of TLR activation. ► Infection-enhancing lipopeptides should be studied as adjuvants for live-attenuated vaccines.