α1-giardin based live heterologous vaccine protects against Giardia lamblia infection in a murine model

► Giardia lamblia is a leading protozoan cause of diarrheal disease worldwide. ► Preventive medical strategies are not available against giardiasis. ► Immunization of mice with a live α1-giardin vaccine protected against infection. ► α1-giardin is highly conserved between divergent Giardia isolates.