The cost-effectiveness of pentavalent rotavirus vaccination in England and Wales

► Cost-effectiveness of introducing rotavirus vaccine modeled using dynamic epidemiological model. ► Taking into account herd protection increases probability that vaccine is cost-effective. ► Threshold analysis determines the probability of cost-effectiveness as a function of vaccine price. ► Vaccine can be cost-effective under a range of plausible vaccine prices for a range of scenarios. ► Quick payback of any cost outlay by reduction in healthcare costs.