Evaluating functional antibodies in rhesus monkeys immunized with hepatitis B virus surface antigen vaccine with novel adjuvant formulations

► We developed a mAb inhibition assay to evaluate functional antibody to HBV. ► Using this assay, we evaluated a potential adjuvant formulations with ISS1018 or ISCOMATRIX™ adjuvant with HBsAg VLP in rhesus monkeys. ► Implications of our findings are discussed.