کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10968228 1102873 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Improved long-term protection against Mycobacterium tuberculosis Beijing/W in mice after intra-dermal inoculation of recombinant BCG expressing latency associated antigens
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Improved long-term protection against Mycobacterium tuberculosis Beijing/W in mice after intra-dermal inoculation of recombinant BCG expressing latency associated antigens
چکیده انگلیسی
► We show expression of latency-associated antigens by recombinant BCG improves longevity of protection against tuberculosis in a murine model. ► This improved protection was achieved against a representative of the medically-relevant Beijing/W lineage of Mycobacterium tuberculosis strains. ► This study provides a proof-of-principle that expression of latency-associated antigens by recombinant BCG can improve vaccine efficacy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 29, Issue 47, 3 November 2011, Pages 8740-8744
نویسندگان
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