Changes in seroprevalence to hepatitis A in Victoria, Australia: A comparison of three time points

► We examined trends in population hepatitis A seroepidemiology over a 20-year period. ► A significant trend of increasing population hepatitis A seroprevalence was observed. ► Temporal increases in seropositivity are in contrast to declining rates of disease. ► These trends may be explained by vaccine uptake, travel and migration patterns.