Associations between single nucleotide polymorphisms and haplotypes in cytokine and cytokine receptor genes and immunity to measles vaccination

► We studied 801 SNPs in 56 genes, in a cohort of 745 MMR-vaccinated schoolchildren. ► We found 48 significant associations with variations in vaccine immune responses. ► We replicated an association of IL12B rs3212227 with variations in humoral immunity. ► We replicated two IL10 and IL2 SNP associations with cellular immunity variations. ► Single SNP and haplotype analysis revealed IL7R associations with vaccine immunity.