Induction and comparison of SIV immunity in Ad5 naïve and Ad5 immune non-human primates using an Ad5 [E1-, E2b-] based vaccine

► Immunization with Ad5 [E1-, E2b-] results in antigen immune induction in Ad5 naïve and Ad5 immune NHP ► Immune responses induced by Ad5 [E1-, E2b-] in Ad5 naïve and Ad5 immune NHP are similar ► Immune responses were induced to an additional antigen targets in hyper Ad5 immune NHP ► The Ad5 [E1-, E2b-] platform induces immune responses in homologous vaccination regimes.