Uptake of various yeast genera by antigen-presenting cells and influence of subcellular antigen localization on the activation of ovalbumin-specific CD8 T lymphocytes

► We compare interaction of various yeast genera with human dendritic cells. ► Kinetic patterns of uptake varies between the yeast genera. ► We compare activation of murine ovalbumin-specific CD8 T cells. ► Subcellular antigen location and genus influence strength of T cell activation. ► Antigen secretion might not be an effective antigen delivery pathway in yeast.