Use of the 13-valent conjugate vaccine has the potential to eliminate pilus carrying isolates as causes of invasive pneumococcal disease

► Changes in the proportion of piliated isolates after vaccination (PCV7) of children. ► Decline of the isolates carrying PI-1 in the post-PCV7. ► Increase of isolates carrying PI-2 in the post-PCV7. ► Confirmed the association of PI-1 with antibiotic resistance. ► Establish the association of PI-2 with antibiotic susceptibility.