Re-circulation of lymphocytes mediated by sphingosine-1-phosphate receptor-1 contributes to resistance against experimental infection with the protozoan parasite Trypanosoma cruzi

► We detected specific CD8+ T cells to Trypanosoma cruzi after infection. ► Specific CD8+ T cells are primed in the draining lymph nodes. ► We administered the functional antagonist of S1P1 (FTY-720) prior to infection. ► FTY-720 administration reduced re-circulation of specific CD8+ T cells to the spleen. ► FTY-720 administration reduced immunity to infection and genetic vaccination.