Adjuvant effect of Japanese herbal medicines on the mucosal type 1 immune responses to human papillomavirus (HPV) E7 in mice immunized orally with Lactobacillus-based therapeutic HPV vaccine in a synergistic manner

► Adjuvant effect of Japanese herbal medicines and LTB on mucosal immune response. ► Synergistic adjuvant effect of Japanese herbal medicines and Lactobacillus casei. ► Enhancement of type 1 immune response induced by oral HPV therapeutic vaccine. ► New strategy for therapeutic vaccine against HPV-related intraepithelial neoplasia.