Antibody response to the central unglycosylated region of the respiratory syncytial virus attachment protein in mice

► We measured RSV G central core-specific IgG in RSV convalescent mouse sera. ► Primary RSV infection elicits virus subtype-specific IgG vs. aa 173-190. ► Such subtype specificity remains unaffected by subtype of secondary infection. ► Homosubtypic secondary RSV infection elicits homosubtypic IgG vs. aa 151-190. ► RSV G-specific IgG antigen avidity/affinity increases after secondary infection.