Human papillomavirus 16 L1-E7 chimeric virus like particles show prophylactic and therapeutic efficacy in murine model of cervical cancer

► We have generated CVLPs as a candidate vaccine for HPV16 infection. ► CVLPs showed humoral immune response in mice. ► CVLPs elicited significant antigen-specific therapeutic effects. ► Antitumor efficacy was seen in a mouse model of cervical cancer.