Fine specificity and cross-reactions of monoclonal antibodies to group B streptococcal capsular polysaccharide type III

► Group B streptococcal type III capsular polysaccharide (CPSIII) is an important Ag. ► We compared a panel of different mAbs to CPSIII using multiple immunoassays. ► MAbs showed unique patterns of fine specificity and host-reactivity. ► These studies raise caution in developing CPSIII-based vaccines.