Immunogenicity following the first and second doses of 7-valent pneumococcal conjugate vaccine in HIV-infected and -uninfected infants

► Infants born to HIV+ mothers have low pneumococcal antibody levels. ► Immune response following two PCV doses in HIV+ is similar to HIV-infants. ► Three PCV doses are required for good immune responses to serotype 6B and 23F. ► A 2 dose PCV primary-series may result in an immunity-gap during early infancy.