کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10968673 | 1102899 | 2011 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pharmacology and toxicology of an oral tablet whole cells inactivated cholera vaccine in Sprague Dawley rats
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
Here we further investigate the pharmacological and toxicological properties of a cholera vaccine based on inactivated whole cells presented in either enteric coated (COA) or uncoated (U/C) tablet formulation from Vibrio cholerae C7258 strain. Tablets were dispersed in 2Â mL drinking water and administered orally to Sprague Dawley rats distributed in five groups (I COA7, II U/C7 immunized at 0, 7, 69Â days and III COA14, IV U/C14 immunized at 0, 14, 69Â days and V control group). Serum vibriocidal antibody response was measured after the administration of two doses with an interval of 7-14Â days. To further investigate the toxicological aspects a third dose was applied 10 weeks after the initial one. Animals were observed daily and water and food consumption was measured every other day. Periodic blood extractions were performed for hematology, biochemistry, and the titer of serum vibriocidal antibodies was determined. Anatomopathological analysis was performed at days 3 or 14 after the third dose. Results from clinical observations, as well as from water and food consumption and body weigh indicated no toxicity of the vaccine product. Meanwhile, no biological differences were found among different groups in hematological, hemo-chemistry, and anatomopathological studies. Moreover, enteric coated and uncoated tablets against human cholera were found to induce an immune response in rats.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 29, Issue 19, 27 April 2011, Pages 3596-3599
Journal: Vaccine - Volume 29, Issue 19, 27 April 2011, Pages 3596-3599
نویسندگان
Yulieé López, Juan Francisco Infante, Sergio Sifontes, Daiyana DÃaz, Viviana Pérez, Gemma Año, Tamara Hernández, Sonsire Fernández, Jorge Luis Castaño, Bárbara Cedré, Reynaldo Oliva, Luis GarcÃa, Rosa L. SolÃs, Arturo Talavera,