HIV vaccine development: Challenges and opportunities towards solving the HIV vaccine-neutralizing antibody problem

► Recent advances have created a renaissance in the search for a safe and effective HIV vaccine. ► Most successful vaccines induce neutralizing antibodies. ► HIV will likely require the induction of broadly neutralizing antibodies (bNAbs), due to the hyper-variability of the virus. ► The current renaissance in neutralizing antibody-based HIV vaccine development, offers significant hope to the future development of safe and globally effective HIV vaccines.