Mechanisms underlying allergy vaccination with recombinant hypoallergenic allergen derivatives

► More than 25% of the population suffer from allergy. ► Allergen-specific immunotherapy has been performed for 100 years. ► Recombinant hypoallergenic allergen derivatives allow a reduction of side-effects. ► As allergy vaccines they can avoid IgE-mediated side effects. ► Therapeutic effects are mainly mediated by allergen-specific blocking IgG antibodies.