کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10968932 1102911 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Experimental autoimmune encephalomyelitis as a testing paradigm for adjuvants and vaccines
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Experimental autoimmune encephalomyelitis as a testing paradigm for adjuvants and vaccines
چکیده انگلیسی
Experimental autoimmune encephalomyelitis (EAE) is an experimental model for multiple sclerosis. EAE can be induced by inoculation with central nervous system (CNS) proteins or peptides emulsified in complete Freund's adjuvant. Protection from EAE, enhancement of EAE or subclinical priming for EAE can occur as a result of either live viral infection or DNA immunization with molecular mimics of CNS proteins or peptides. Here we review the published data describing modulation of EAE through administration of various CNS proteins/peptides introduced via live virus or plasmid DNA and modulation of EAE through choice of adjuvant (immunostimulating agents).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 29, Issue 17, 12 April 2011, Pages 3356-3362
نویسندگان
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