کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10968994 | 1102917 | 2011 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Enhancement of immunogenicity of a virosome-based avian influenza vaccine in chickens by incorporating CpG-ODN
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Enhancement of immunogenicity of a virosome-based avian influenza vaccine in chickens by incorporating CpG-ODN Enhancement of immunogenicity of a virosome-based avian influenza vaccine in chickens by incorporating CpG-ODN](/preview/png/10968994.png)
چکیده انگلیسی
Influenza virosomes are virus-like particles, representing a platform for vaccine development. In this study, we examined the immunogenicity of avian influenza virosomes with or without inclusion of recombinant chicken interferon-gamma (rChIFN-γ) or CpG-ODN in chickens. Immunization with virosomes adjuvanted with CpG-ODN elicited the highest haemagglutination inhibition antibody titres, as well as IgG and IgA serum antibody responses. Moreover, Virosomes + CpG-ODN formulation induced an antigen-specific spleen cell proliferation and IFN-γ expression. In conclusion, our results demonstrated that virus-specific antibody- and cell-mediated responses may be induced in chickens immunized with virosomes and these responses can be enhanced by incorporating CpG-ODN in the virosome vaccine formulation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 29, Issue 8, 11 February 2011, Pages 1657-1665
Journal: Vaccine - Volume 29, Issue 8, 11 February 2011, Pages 1657-1665
نویسندگان
Amirul Islam Mallick, Payvand Parvizi, Leah R. Read, Ãva Nagy, Shahriar Behboudi, Shayan Sharif,