Induction of pulmonary mucosal immune responses with a protein vaccine targeted to the DEC-205/CD205 receptor

► Y. pestis LcrV protein is targeted to dendritic cells via DEC-205 receptor. ► Mucosal immunity is induced by the vaccine through both s.c. and i.n. routes. ► Poly IC is an efficient mucosal adjuvant in the DEC-205 targeting strategy. ► Efficacy of the targeting vaccine is demonstrated in mucosal T and B cell immunity.