Relative stability of meningococcal serogroup A and X polysaccharides

► Complete characterization of meningococcal X CPS by NMR spectroscopy. ► Stability evaluation of meningococcal X CPS by NMR and HPLC methodologies. ► Serogroup A CPS is more susceptible to hydrolytic degradation than serogroup X CPS. ► The stability of serogroup X CPS predicts the possibility of a fully-liquid vaccine.