Evaluation of recombinant E2 protein-based and whole-virus inactivated candidate vaccines against chikungunya virus

► Chikungunya virus vaccines: recombinant E2 protein and inactivated virus based. ► High level of ELISA/neutralizing antibody (nAb) titres elicited in vaccinated mice. ► nAbs were cross reactive with heterologous genotype of virus. ► Long lasting complete protection by all candidate vaccines. ► Alum being the most effective adjuvant.