کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10969444 | 1102960 | 2010 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Immunogenicity of RepliVAX WN, a novel single-cycle West Nile virus vaccine
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Immunogenicity of RepliVAX WN, a novel single-cycle West Nile virus vaccine Immunogenicity of RepliVAX WN, a novel single-cycle West Nile virus vaccine](/preview/png/10969444.png)
چکیده انگلیسی
We recently reported that immunization with RepliVAX WN, a single-cycle West Nile virus (WNV) vaccine, protected mice against WNV challenge. We have extended these studies by characterizing the RepliVAX WN-elicited antibody and T cell responses. WNV-specific IgG antibody responses comprised predominantly of IgG2c and IgG2b subclasses were detected 8 months after immunization. Vigorous WNV-specific CD4+ and CD8+ T cell responses directed at both structural and nonstructural WNV proteins were detected which were characterized by cytolytic activity and secretion of IFN-γ and TNF-α. Importantly, RepliVAX WN immunization resulted in vigorous CD8+ memory T cell responses detected at 8 months after immunization.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 29, Issue 2, 16 December 2010, Pages 174-182
Journal: Vaccine - Volume 29, Issue 2, 16 December 2010, Pages 174-182
نویسندگان
Michelle H. Nelson, Evandro Winkelmann, Yinghong Ma, Jingya Xia, Peter W. Mason, Nigel Bourne, Gregg N. Milligan,