Vaccination and acute phase mediator production in chickens challenged with low pathogenic avian influenza virus; novel markers for vaccine efficacy?

► Vaccine efficacy for LPAI in chickens is difficult to experimentally determine. ► We examined production of acute phase mediators as a marker of vaccine efficacy. ► Vaccinated chickens produced less acute phase mediators than unvaccinated chickens. ► Acute phase mediator production may help define LPAI vaccine efficacy in chickens.