Children with otitis media mount a pneumococcal serotype specific serum IgG and IgA response comparable to healthy controls after pneumococcal conjugate vaccination

► Otitis-prone children do not have impaired antibody responses to PCV7. ► Otitis-prone children have higher natural IgG levels to the pneumococcus than controls. ► A second dose of PCV7 increases IgG, but not IgA levels. ► Otitis-prone children getting 1 or 2 doses of PCV7 have similar IgG/A levels at one year.