کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10969674 | 1102977 | 2010 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Impaired generation of hepatitis B virus-specific memory B cells in HIV infected individuals following vaccination
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Hepatitis B-specific memory B cell (HSMBC) frequencies were measured following hepatitis B vaccination in 15 HIV uninfected and 12 HIV infected adolescents. HSMBC were detected at significantly lower frequencies in HIV infected than in HIV uninfected individuals. The detection of HBsAb >10Â mIU/ml at study week 28 was strongly associated with the detection of HSMBC and a direct correlation between HBsAb titers and HSMBC frequencies was observed. In HIV uninfected individuals, antibody titers >1000Â mIU/ml were associated with higher HSMC frequencies. Lower HSMBC frequencies, reduced memory B cell (MBC) proliferation, and altered B cell phenotypes were measured in viremic HIV infected individuals compared with aviremic HIV infected or HIV uninfected individuals.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 28, Issue 21, 7 May 2010, Pages 3672-3678
Journal: Vaccine - Volume 28, Issue 21, 7 May 2010, Pages 3672-3678
نویسندگان
Nishaki Mehta, Coleen K. Cunningham, Patricia Flynn, Joyce Pepe, Stephen Obaro, Bill G. Kapogiannis, James Bethel, Katherine Luzuriaga, Adolescent Trials Network for HIV/AIDS Interventions Adolescent Trials Network for HIV/AIDS Interventions,