Wheat germ agglutinin enhanced cerebral uptake of anti-Aβ antibody after intranasal administration in 5XFAD mice

► WGA enhanced cerebral uptake and binding of anti-Aβ antibody to the native Aβ plaques. ► WGA also facilitated intraneuronal penetration of anti-Aβ antibody. ► WGA is a novel vehicle for maximizing intranasal passive immunization in Alzheimer's disease.