A candidate dual vaccine against influenza and noroviruses

► A P particle-M2e chimeric vaccine was generated by insertion of human influenza A M2e epitope into norovirus P particle. ► Mice developed significantly increased IgG against M2e after immunization with this chimeric vaccine and 100% survived from a lethal challenge with influenza virus. ► Antibodies induced by the chimeric vaccine blocked norovirus VLP and P particle binding to HBGA receptors, suggesting an opportunity to develop a dual vaccine against both influenza and noroviruses.