Structural modification effects on bioactivities of the novel 15-mer peptide adjuvant

► GMDP peptide mimic, RVPPRYHAKISPMVN (RN-peptide) as a new non-pyrogenic adjuvant. ► Structure-activity relationship studies of shortened and Ala-scan analogues of RN-peptide. ► PRYH is ultimately required for binding to anti-GMDP-antibodies. ► RVPPRYH is a minimal peptide segment possessing adjuvant activity. ► Ala-scan approach revealed K9, I10, S11, М13 contributions into RN adjuvant activity.