کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10969887 1102996 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A universal anti-HIV-1 Tat epitope vaccine that is fully synthetic and self-adjuvanting
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
A universal anti-HIV-1 Tat epitope vaccine that is fully synthetic and self-adjuvanting
چکیده انگلیسی
Circulating HIV-1 Tat protein is essential for maintenance of the chronic HIV replication that predicates both HIV transmission and clinical progression to AIDS/death. A synthetic anti-Tat epitope vaccine (TUTI-16) was designed to induce neutralizing antibodies to Tat and, hopefully, provide immunological control of HIV replication. TUTI-16 is composed of (1) a conserved Tat B cell epitope (Tat 4-12), rendered universal by introducing known variant amino acids at variable positions 7, 9 and 12 during solid phase synthesis, (2) a promiscuous T helper sequence and (3) a lipopeptide toll-like receptor 2 (TLR2) agonist. TUTI-16 induced high titer antibodies against all 8 known variants of the Tat epitope.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 28, Issue 4, 22 January 2010, Pages 1008-1014
نویسندگان
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