کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10970107 | 1103024 | 2009 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Immunogenicity and safety of intradermal versus intramuscular route of influenza immunization in infants less than 6 months of age: A randomized controlled trial
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Immunogenicity and safety of intradermal versus intramuscular route of influenza immunization in infants less than 6 months of age: A randomized controlled trial Immunogenicity and safety of intradermal versus intramuscular route of influenza immunization in infants less than 6 months of age: A randomized controlled trial](/preview/png/10970107.png)
چکیده انگلیسی
We aimed to explore intradermal influenza vaccination in infants <6 months. One hundred twenty-six infants 2-3 months of age were randomized to receive either two doses, 1 month apart, of 0.25 ml of a trivalent inactivated influenza vaccine (7.5 μg of hemagglutinin per strain) via the intramuscular (IM) route or 0.1 ml of the same vaccine (3 μg of hemagglutinin per strain) via the intradermal (ID) route. The vaccine was well tolerated. Only four infants had hemagglutination inhibition (HAI) titer <40 against â¥1 vaccine-covered antigen pre-vaccination. There was no difference in fold-rise of HAI titer response between those in the IM or ID group. We documented maintenance of HAI titers above seroprotective levels against all three vaccine antigens in 97.6% of subjects regardless of vaccination methods over a time of waning maternal antibodies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 27, Issue 35, 30 July 2009, Pages 4834-4839
Journal: Vaccine - Volume 27, Issue 35, 30 July 2009, Pages 4834-4839
نویسندگان
Susan S. Chiu, Kwok-Hung Chan, Wenwei Tu, Yu Lung Lau, J.S. Malik Peiris,