کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10970256 | 1103039 | 2010 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Novel Chlamydia pneumoniae vaccine candidates confirmed by Th1-enhanced genetic immunization
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Novel Chlamydia pneumoniae vaccine candidates confirmed by Th1-enhanced genetic immunization Novel Chlamydia pneumoniae vaccine candidates confirmed by Th1-enhanced genetic immunization](/preview/png/10970256.png)
چکیده انگلیسی
Identification of highly immunogenic antigens is critical for the construction of an efficacious subunit vaccine against Chlamydia pneumoniae infections. A previous project used a genome-wide screen to identify 12 protective C. pneumoniae candidate genes in an A/J mouse lung disease model (Li et al. [14]). Due to insufficient induction of Th1 immunity, these genes elicited only modest protection. Here, we used the Escherichia coli heat-labile enterotoxin as a Th1-enhancing genetic adjuvant, and re-tested these 12 genes, in parallel with six genes identified by other investigators. Vaccine candidate genes cutE and Cpn0420 conferred significant protection by all criteria evaluated (prevention of C. pneumoniae-induced death, reduction of lung disease, elimination of C. pneumoniae). Gene oppA_2 was protective by disease reduction and C. pneumoniae elimination. Four other genes were protective by a single criterion. None of the six genes reported elsewhere protected by reduction of lung disease or elimination of C. pneumoniae, but three protected by increasing survival.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 28, Issue 6, 10 February 2010, Pages 1598-1605
Journal: Vaccine - Volume 28, Issue 6, 10 February 2010, Pages 1598-1605
نویسندگان
Yihang Li, Sudhir K. Ahluwalia, Alexandre Borovkov, Andrey Loskutov, Chengming Wang, Dongya Gao, Anil Poudel, Kathryn F. Sykes, Bernhard Kaltenboeck,