کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10970377 | 1103069 | 2009 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Therapeutic efficacy of a multi-epitope vaccine against Helicobacter pylori infection in BALB/c mice model
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Therapeutic efficacy of a multi-epitope vaccine against Helicobacter pylori infection in BALB/c mice model Therapeutic efficacy of a multi-epitope vaccine against Helicobacter pylori infection in BALB/c mice model](/preview/png/10970377.png)
چکیده انگلیسی
Epitope vaccine is a promising option for therapeutic vaccination against Helicobacter pylori (H. pylori) infection. In this study, we constructed a multi-epitope vaccine with five epitopes and mucosal adjuvant E. coli heat-labile enterotoxin B subunit (LTB) named HUepi-LTB and evaluated its therapeutic effect against H. pylori infection in BALB/c mice model. HUepi-LTB containing three Th epitopes from UreB and two B cell epitopes from UreB and HpaA was constructed and expressed in E. coli. Oral therapeutic immunization with HUepi-LTB significantly decreased H. pylori colonization compared with oral immunization with PBS, and the protection was correlated with antigen-specific CD4+ T cells and IgG and mucosal IgA antibody responses. This multi-epitope vaccine may be a promising vaccine candidate that may help to control H. pylori infection.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 27, Issue 36, 6 August 2009, Pages 5013-5019
Journal: Vaccine - Volume 27, Issue 36, 6 August 2009, Pages 5013-5019
نویسندگان
Wei-Ying Zhou, Yun Shi, Chao Wu, Wei-Jun Zhang, Xu-Hu Mao, Gang Guo, Hai-Xia Li, Quan-Ming Zou,