کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10970405 | 1103119 | 2009 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Meningococcal interactions with the host
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Meningococcal interactions with the host Meningococcal interactions with the host](/preview/png/10970405.png)
چکیده انگلیسی
Neisseria meningitidis interacts with host tissues through hierarchical, concerted and co-ordinated actions of a number of adhesins; many of which undergo antigenic and phase variation, a strategy that helps immune evasion. Three major structures, pili, Opa and Opc predominantly influence bacterial adhesion to host cells. Pili and Opa proteins also determine host and tissue specificity while Opa and Opc facilitate efficient cellular invasion. Recent studies have also implied a role of certain adhesin-receptor pairs in determining increased host susceptibility to infection. This chapter examines our current knowledge of meningococcal adhesion and invasion mechanisms particularly related to human epithelial and endothelial cells which are of primary importance in the disease process.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 27, Supplement 2, 24 June 2009, Pages B78-B89
Journal: Vaccine - Volume 27, Supplement 2, 24 June 2009, Pages B78-B89
نویسندگان
Etienne Carbonnelle, Darryl J. Hill, Philippe Morand, Natalie J. Griffiths, Sandrine Bourdoulous, Isabel Murillo, Xavier Nassif, Mumtaz Virji,