کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10970425 1103133 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Complement and antibodies: A dangerous liaison in HIV infection?
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Complement and antibodies: A dangerous liaison in HIV infection?
چکیده انگلیسی
Due to ongoing recombination and mutations, HIV permanently escapes from neutralizing antibody (nAb) responses of the host. By the masking of epitopes or shedding of gp120, HIV-1 further impedes an efficient neutralization by Abs. Therefore, nAbs responses of the host are chasing behind a rapidly evolving virus and mainly non-neutralizing antibodies (non-nAbs) are present in the host. At the same time, complement deposition on immune-complexed HIV may counteract the immune response by enhancing the infection. On the other hand, complement-mediated lysis is a putative effector mechanism to control viral replication. Here we review the complex interplay between complement, neutralizing and non-neutralizing Abs during HIV infection and discuss the contribution of Abs and complement in blocking versus enhancing the course of infection.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 26, Supplement 8, 30 December 2008, Pages I79-I85
نویسندگان
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