کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10970526 | 1103229 | 2007 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Gantrez® AN nanoparticles as an adjuvant for oral immunotherapy with allergens
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
The aim of this study was to investigate the adjuvant properties of oral-administered Gantrez® AN nanoparticles with ovalbumin (as allergen model) and, in some cases, lipopolysaccharide of Brucella ovis as immunomodulator. For this purpose, BALB/c mice were administered by oral gavage with OVA nanoparticles and both Th1 and Th2 markers (IgG2a and IgG1, respectively) were enhanced. On the other hand, these carriers administered by oral route were able to protect a model of sensitized mice to ovalbumin from anaphylactic shock. These results are highly suggestive for the valuable use of Gantrez® nanoparticles in oral immunotherapy with allergens.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 25, Issue 29, 20 July 2007, Pages 5263-5271
Journal: Vaccine - Volume 25, Issue 29, 20 July 2007, Pages 5263-5271
نویسندگان
Sara Gómez, Carlos Gamazo, Beatriz San Roman, Marta Ferrer, Maria Luisa Sanz, Juan M. Irache,