کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10970538 | 1103229 | 2007 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
TLR2 activation by proteosomes promotes uptake of particulate vaccines at mucosal surfaces
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
Proteosome-based vaccines have TLR2-based adjuvant activity and show promise for mucosal immunization. We examined the effects of proteosomes on mucosal uptake in Peyer's patches in vivo. Proteosomes accelerated transepithelial transport of microparticles by M cells and induced migration of dendritic cells (DCs) into the follicle-associated epithelium (FAE); both effects were dependent on TLR2. Proteosomes induced the release of the DC-attracting chemokine MIP3α from Caco-2 epithelial cells in vitro. In HEK cells, proteosome-mediated MIP3α release was dependent on TLR2 expression and matrix metalloproteinase activation. Thus, TLR2 activation by proteosomes may promote mucosal uptake of particulate vaccines, and this may contribute to their adjuvanticity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 25, Issue 29, 20 July 2007, Pages 5348-5358
Journal: Vaccine - Volume 25, Issue 29, 20 July 2007, Pages 5348-5358
نویسندگان
Sophie M. Chabot, Tyler S. Chernin, May Shawi, Jessica Wagner, Stephanie Farrant, David S. Burt, Sonya Cyr, Marian R. Neutra,