کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10972076 1106768 2013 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
β-glucan enriched bath directly stimulates the wound healing process in common carp (Cyprinus carpio L.)
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم آبزیان
پیش نمایش صفحه اول مقاله
β-glucan enriched bath directly stimulates the wound healing process in common carp (Cyprinus carpio L.)
چکیده انگلیسی
The aim of the present study was to investigate the biological impact of two different commercially available β glucan containing products on the wound healing process in carp. Throughout a two week experiment fish were kept either untreated (control), or in water supplemented with the two different types of β-glucans. The wound healing process was monitored using a multispectral visualisation system. The correlation between wound closure and immune response was investigated by measuring the gene expression patterns of IL-1β, IL-6 family member M17, IL-8 and Muc5b, and measurement of production of radical oxygen species. PAMPs/DAMPs stimulation caused by the wounding and or β-glucans resulted in an inflammatory response by activating IL-1β, IL-6 family member M17 and IL-8 and differences in the expression pattern were seen depending on stimuli. IL-1β, IL-6 family member M17 and IL-8 were activated in all wounds regardless of treatment. Expression of all three interleukins was highly up regulated in control wounded muscle already at day 1 post-wounding and decreased at subsequent time-points. The reverse was the case with control wounded skin, where expression increased from day 1 through day 14. The results for the β-glucan treated wounds were more complex. The images showed significantly faster wound contraction in both treated groups compared to the control. The obtained results clearly demonstrated that a β glucan enriched bath promotes the closure of wounds in common carp and induce a local change in cytokine expression.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fish & Shellfish Immunology - Volume 35, Issue 3, September 2013, Pages 998-1006
نویسندگان
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