A high-throughput assay for the identification of malarial transmission-blocking drugs and vaccines

► A novel Plasmodium transmission-stage screening assay is reported. ► The assay used in this study is high throughput, easy to perform and reliable. ► The assay is able to identify both transmission-blocking drugs and antibodies. ► The utility of the assay was demonstrated by screening 40 known and marketed antimalarial drugs. ► The assay will be of use in identifying new transmission-blocking interventions.