Immunisation against a serine protease inhibitor reduces intensity of Plasmodium berghei infection in mosquitoes

- Vaccines that prevent transmission of Plasmodium parasites from mosquitoes would help towards eradicating malaria.
- Most such transmission-blocking vaccines target parasite antigens expressed within the mosquito.
- A vaccine is described which induced antibodies against a regulatory component of the mosquito innate immune response.
- These antibodies reduce the intensity of Plasmodium berghei infection in mosquitoes.
- This may be a novel approach to malaria transmission-blocking vaccines.