Toxoplasma gondii inhibits granzyme B-mediated apoptosis by the inhibition of granzyme B function in host cells

► Toxoplasma gondii protects host cells from granzyme B-induced apoptosis. ► T. gondii prevents cleavage of granzyme B substrates in host cells ►. Reduced granzyme B activity is not due to abnormal granzyme uptake or trafficking. ► T. gondii inhibits the activity of granzyme B delivered by cytotoxic lymphocytes.