کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
11001412 | 1432566 | 2018 | 27 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A pilot Indian family-based association study between dyslexia and Reelin pathway genes, DCDC2 and ROBO1, identifies modest association with a triallelic unit TAT in the gene RELN
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کلمات کلیدی
L1 and L2GIHMAFBengaliDSM-IVNCRFamily Based Association TestDcdc2ITUFBATRobo1 - robo1BEB - بی بیLinkage disequilibrium - عدم تعادل پیوستگیminor allele frequency - فراوانی آللی جزئیNeuronal migration - مهاجرت نورونDyslexia - نارساخوانیSingle nucleotide polymorphism - پلیمورفیسم تک نوکلئوتیدیSNP - چندریختی تک-نوکلئوتید
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: A pilot Indian family-based association study between dyslexia and Reelin pathway genes, DCDC2 and ROBO1, identifies modest association with a triallelic unit TAT in the gene RELN A pilot Indian family-based association study between dyslexia and Reelin pathway genes, DCDC2 and ROBO1, identifies modest association with a triallelic unit TAT in the gene RELN](/preview/png/11001412.png)
چکیده انگلیسی
Twenty two functional variants across six RELN signalling genes (RELN, VLDLR, APOER2, DAB1, LIS1 and NDEL1) and two dyslexia candidate genes (DCDC2 and ROBO1) were analyzed for association in twenty six nuclear and three extended families with individuals affected with dyslexia. Univariate association analysis was suggestive of association (puncorrectedâ=â0.01) with rs362746 in RELN which however did not withstand Bonferroni corrections (pcorrectedâ=â0.21). Multimarker tests indicated significant association (pâ=â0.037), based on which we tested for haplotype associations. Although there were no significant haplotypic associations, we found that a three marker unit with rs3808039 and rs2072403 flanking and independently in linkage disequilibrium with rs362746 was significantly overtransmitted (risk allelic combination - TAT) to dyslexia affected individuals in the sample (pâ=â0.002). Our results suggest preliminary evidence for a new potential risk variant in the RELN locus for dyslexia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Asian Journal of Psychiatry - Volume 37, October 2018, Pages 121-129
Journal: Asian Journal of Psychiatry - Volume 37, October 2018, Pages 121-129
نویسندگان
Subhashree Devasenapathy, Rashi Midha, Teesta Naskar, Anuradha Mehta, Bharat Prajapati, Mariam Ummekulsum, Rajesh Sagar, Nandini C. Singh, Subrata Sinha,