کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
11021264 | 1714849 | 2018 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A neurobiological pathway to smoking in adolescence: TTC12-ANKK1-DRD2 variants and reward response
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
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چکیده انگلیسی
The TTC12-ANKK1-DRD2 gene-cluster has been implicated in adult smoking. Here, we investigated the contribution of individual genes in the TTC12-ANKK1-DRD2 cluster in smoking and their association with smoking-associated reward processing in adolescence. A meta-analysis of TTC12-ANKK1-DRD2 variants and self-reported smoking behaviours was performed in four European adolescent cohorts (Nâ¯=â¯14,084). The minor G-allele of rs2236709, mapping TTC12, was associated with self-reported smoking (pâ¯=â¯5.0â¯Ãâ¯10â4) and higher plasma cotinine levels (pâ¯=â¯7.0â¯Ãâ¯10â5). This risk allele was linked to an increased ventral-striatal blood-oxygen level-dependent (BOLD) response during reward anticipation (nâ¯=â¯1,263) and with higher DRD2 gene expression in the striatum (pâ¯=â¯0.013), but not with TTC12 or ANKK gene expression. These data suggest a role for the TTC12-ANKK1-DRD2 gene-cluster in adolescent smoking behaviours, provide evidence for the involvement of DRD2 in the early stages of addiction and support the notion that genetically-driven inter-individual differences in dopaminergic transmission mediate reward sensitivity and risk to smoking.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Neuropsychopharmacology - Volume 28, Issue 10, October 2018, Pages 1103-1114
Journal: European Neuropsychopharmacology - Volume 28, Issue 10, October 2018, Pages 1103-1114
نویسندگان
Christine Macare, Francesca Ducci, Yuning Zhang, Barbara Ruggeri, Tianye Jia, Marika Kaakinen, Gursharan Kalsi, Pimphen Charoen, Filippo Casoni, Jan Peters, Uli Bromberg, Matthew Hill, Jessica Buxton, Alexandra Blakemore, Juha Veijola, Christian Büchel,