کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
11023084 | 1701346 | 2018 | 34 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Increased sleep time and reduced energy expenditure contribute to obesity after ovariectomy and a high fat diet
ترجمه فارسی عنوان
افزایش زمان خواب و کاهش مصرف انرژی موجب چاقی بعد از تخمدان و رژیم غذایی با چربی بالا می شود
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کلمات کلیدی
چاقی مصرف غذا، ترکیب بدنی، فشار خون، یک هورمون جنسی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی
In this study we examined if sleep time, caloric intake and energy expenditure are important contributors to development of ovariectomy-induced obesity in mice fed control or high fat diet (HFD). Twelve female mice at 6â¯weeks of age were divided into 2 groups: Sham (nâ¯=â¯5) and ovariectomized (OVX, nâ¯=â¯7). Mice were fed control diet for 9â¯weeks and shifted to HFD for additional 9â¯weeks. Food intake and body weight were measured daily and body composition was measured weekly by EchoMRI. Energy expenditure (EE), oxygen consumption (VO2), motor activity (MA) and sleep time were monitored at week 9 during control diet and HFD. OVX did not alter caloric intake, body weight or body composition, MA, sleep time or fasting blood glucose, but slightly reduced EE compared to Sham mice on control diet. After HFD feeding, OXV mice had similar caloric intake, lean mass, MA, and blood glucose levels but had significantly greater weight gain (8.2â¯Â±â¯1.0 vs. 4.8â¯Â±â¯1.2â¯g, pâ¯<â¯0.05), increased fat mass and sleep time, and reduced EE (3.3â¯Â±â¯0.4 vs. 5.5â¯Â±â¯0.2â¯kcal/h) and VO2 (1.12â¯Â±â¯0.01 vs. 1.83â¯Â±â¯0.05â¯ml/min) compared to Sham group. Daytime blood pressure was higher while nighttime heart rate was lower in OVX group. These results suggest that OVX may not substantially alter body weight or body composition in mice fed a normal diet, but when combined with HFD it increases sleep time and reduces EE, leading to greater weight gain and adiposity without altering food intake.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Life Sciences - Volume 212, 1 November 2018, Pages 119-128
Journal: Life Sciences - Volume 212, 1 November 2018, Pages 119-128
نویسندگان
Jussara M. do Carmo, Alexandre A. da Silva, Sydney P. Moak, Jackson R. Browning, Xuemei Dai, John E. Hall,