کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
11025655 | 1666540 | 2019 | 43 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Usefulness of the EpiSkin⢠reconstructed human epidermis model within Integrated Approaches on Testing and Assessment (IATA) for skin corrosion and irritation
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کلمات کلیدی
PBSguidance documentSCVSCATEURL ECVAMSOPECVAM Scientific Advisory CommitteeCAS RNEU CLPESACμLOECDUN GHS - GHSMTT - MTTEuropean Union Reference Laboratory for Alternatives to Animal Testing - آزمایشگاه مرجع اتحادیه اروپا برای جایگزینی برای تست حیواناتEuropean Union - اتحادیه اروپاTop-down - بالا پایینNo Cat - بدون گربهPercent - درصدCategory - دسته بندیTest guidelines - دستورالعمل های تستChemical Abstracts Service Registry Number - رجیستری شماره سرویس های شیمیاییstandard operating procedure - روش های عملیاتی استانداردUnited Nations Globally Harmonized System of Classification and Labelling of Chemicals - سازمان ملل متحد سیستم جهانی طبقه بندی و برچسب زدن مواد شیمیاییOrganization for Economic Co-operation and Development - سازمان همکاری و توسعه اقتصادیDulbecco's phosphate-buffered saline - فسفات باسیل نمک DulbeccoMillilitre - میلی لیترMicroliter - میکرولیترBottom-up - پایین پایینoptical density - چگالی نوریIATA - یاتا
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Predictive capacity of the EpiSkin⢠model was evaluated on 87 chemicals using the Bottom-Up and the Top-Down testing approaches recommended within Integrated Approach on Testing and Assessment for the identification of both skin irritation and corrosion hazards. Classified (UN GHS Cat. 1 and Cat. 2) chemicals were identified with a very high sensitivity (â¥94%) and the non-classified (UN GHS Cat. 3 and No Cat.) chemicals with an appropriate specificity (70%). Very high sensitivities were obtained for the identification of Cat. 1 chemicals (â¥98%), very high specificities for non-Cat. 1 chemicals (93%), and accuracies of â95% for the identification of skin corrosives vs. non-corrosives by both approaches. Overall accuracies of 72% were found for predicting the single (sub)categories: non-classified, Cat. 2, Subcat. 1B/1C and Subcat. 1A. Results indicated the testing strategies to be more predictive than the individual assays on a conservative safety approach. Finally, no extreme misclassifications (no under-prediction of in vivo Subcat. 1A as non-Cat. 1, and no over-prediction of non-classified chemical as Subcat. 1A) occur. These findings, independently of the approach used, confirm the usefulness of the EpiSkin⢠in vitro model for a safe prediction of the skin irritant and corrosive hazards of chemicals.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology in Vitro - Volume 54, February 2019, Pages 147-167
Journal: Toxicology in Vitro - Volume 54, February 2019, Pages 147-167
نویسندگان
Nathalie Alépée, Marie-Hélène Grandidier, José Cotovio,