New bis-(3-hydroxy-4-pyridinone)-NTA-derivative: Synthesis, binding ability towards Ca2+, Cu2+, Zn2+, Al3+, Fe3+ and biological assays

A new bis-(3-hydroxy-4-pyridinone) ligand, NTA(PrHP)2, with illustration of the its metal chelation capacity and selectivity based on the pM values calculated vs. pH for the different Mn+/ligand systems (a, Ca2+ = , Cu2+ = , Zn2+ = , Al3+ = , Fe3+ = ○) and its in vivo excretion capacity in animal model (mice overload with 67Ga) (b).118