Thermodynamic analysis and molecular dynamic simulation of the solubility of vortioxetine hydrobromide in three binary solvent mixtures

RDF plots in the absence and presence of vortioxetine hydrobromide in butanone + n-butanol binary solvent mixtures at different solvent compositions of n-butanol. The data suggests both solute-solvent and solvent-solvent interactions contribute to the solubility behavior (cosolvency formation) of vortioxetine hydrobromide in binary mixed solvents.78